As far as an altitude situation and poor blood flow, that is a bit over my head as I live at 680 above sea level! I have been using Isoxsuprine as a reproductive aid in some mares for over 12 years and as far as a reproductive aid, I believe there is no published research, although, if you look at the activity of the drug it makes absolute sense. As you know, Isoxsuprine is a vasodilator, which increases blood flow, and for foundered mares, there are tremendous amounts of capillaries in the coffin bone and when a diminished blood occurs, a vasodilator improves this situation. As far as a reproductive aid, the uterus is made up of a tremendous amount of capillaries and as we know, older mares do not feed a baby in utero as well as a young mare so this theory has a solid base from which to stand. In my experience using Isoxsuprine, I have found that the foals tend to have a heavier birth weight and the foal seems to have more vigor. By all means, I am not saying that every mare requires Isoxsuprine to produce good foals, although, it is an aid that from my experience has a proven track record. Please remember, I would consult your veterinarian first as Isoxsuprine is a drug that is regulated by the FDA.

Sincerely,
Jon P. Wiesman, President

To date I do not sell any hormones, although, I do plan to be offering them in the near future. Please remember, it is always wise to have a reproductive status performed by your veterinarian before you start to administer any component that would alter the reproductive efficiency of an animal. This would include the use of Regumate®, Prostaglandin i.e.: Lutalase or Estramate, F.S.H. (Follicle Stimulating Hormone), H.C.G. (Human Chorionic Gonadotropin). If you need any assistance or future information, feel free to contact me at your convenience, again, thank you for your interest in my company.

Using our A.V. fill kit, I would use Alconox several times to fill your A.V., which is an anti-bacterial and an anti-fungal all in one! This may help to some extent.

You may not be able to get the "Black Spots" out of the interior of your A.V., hopefully we can slow down its natural disintegration of the Gum Rubber. Once those "Black Spots" begin you will be lucky to get two more years of service out of you're A.V., although, you must always keep in mind about the possibility of seminal contamination when mold is present. Feel free to call me on Monday and I can give you a few more ideas in an attempt to rejuvenate your AV. for another year of service. Again, thank you.

Sincerely,

Jon P. Wiesman, President
Exodus Breeders Corporation

Here are a few tips for the proper processing of equine semen

25 to 30 million progressively motile sperm per milliliter
750 million progressively motile sperm per insemination dose
Base extension rates of 5:1 are recommended although, some stallions may require a higher ratio

Ask your stallion farm a few of the questions that I have outlined above and see exactly what they know, and answers to your barrenness and/or reproductive problems in your breeding program may become crystal clear!

Sincerely,

Jon P. Wiesman

I have come into something new with this year's breeding. My mare was bred on 5/29. The vet told me she had ovulated approximately one hour before being bred (through palpation). The stallion was shipping at 80% last year and was informed his motility was very high this year. This is the same stallion from my 2004 filly (she was bred AI at the stallion's farm 2003). The stallion was collected at 5pm Friday (5/28/04) evening and she was bred
Saturday (5/29/04) at 8:30am. My mare was ultasounded on day 17 (Tuesday 6/15/04). I saw a few glances at the ultrasound (heaven knows I am not experienced in this, but I'm confused). Forgive my medical terms; she had two round black dots (conceptus?). Not connected. One a little larger than the other. I was told she was showing small signs of folds and her cervix was not as tight as expected. I was told possibly these were cysts? [J.P.W.] Yes, they could easily be cysts, although, you would of seen them prior to breeding her on this previous cycle, they just do not appear out of no where. She has never had any problems with cysts before. Could they possibly be twins [J.P.W.] Very much so!; and the reason for the folds and her cervix not being tight be due to her absorbing one? [J.P.W.] No, I would think that if she had folds starting to form, she probably does not have a prominent CL and that hormone is what maintains a pregnancy through day 135, producing progesterone until it switches over to the placenta. If your veterinarian did not also scan the ovaries to eliminate this out of his diagnosis, the mare will most likely recycle herself because she has no hormone or a limited concentration in her blood to maintain the pregnancy. When ever I scan a mare and she has folds beginning to form and I have a conceptus present, I first look for a CL present on one of her ovaries so I know right off the bat if she should be placed on supplemental progesterone whether it be oral (Regumate) or injectable (BETPHARM's P+) What happens with then when the mare trys to absorb one of the twins? [J.P.W.] At this stage in the game, it will have no consequence, that becomes an issue if they loose a pregnancy after day 32 when the endometrial cups have begun to form. Could she be aborting the pregnancy? [J.P.W.] Yes because she has a not enough progesterone present to keep her cervix closed and to fend off the hormone F.S.H. Could they be cysts? [J.P.W.] More than likely not if they were not present in the previous scans from this last cycle that she was bred on. Would cysts affect/risk a pregnancy. [J.P.W.] Well yes and no, I have had cysts lasered out of some older mares before and some it has helped and some, it is just at the end of their reproductive career and it is like breeding your grandmother. Have you ever experience something like this? [J.P.W.] Yes, actually this year we have had two situations with younger mares and had I not told my vet when she questioned me to double check her ovaries for a CL she would of never put the mares on injectable progesterone and Regumate and Isoxsuprine. I would so GREATLY APPRECIATE it if you could give me your opinion on this situation. Again, if you can't I will understand. Thanks again for your time!!!!![J.P.W.] Most likely, with the age of your mare, she did not have what is called a dominant CL present in order to maintain a pregnancy. This can be induced by mother nature telling her that this one is not good or that it is time to take a year off. Although, as we all know, we tend to defy the laws of Mother Nature by using supplemental hormones that would give us the opportunity to have her produce a foal in 2005. Thank you again, your questions are always superior and it is my pleasure to assist you anyway possible.
[J.P.W.] Jon

Belinda Newrones

Tell me your thoughts on this breeding tool, as I would greatly appreciate your comments, Again, thank you. Sincerely,
Jon P. Wiesman, President & CEO
Exodus Breeders Supply

1. Age: A 2 year old is and can be immature and not as willing to breed as easily as a 3 year old would be.
2. Teaching Bad Reproductive Vices: Allowing him to back off a phantom can lead to several bad breeding vices that he may not ever overcome.
3. Natural Cover: This could repair/rebuild his confidence in breeding:
   1. If he is allowed to pull back with out ejaculating this could become a permanent void that will follow him for years.
   2. You may want to turn him out in a paddock by himself for a couple of days with a mare that is in a solid standing heat and he will learn to breed on his own at his own pace.
   3. If you decide to go this route and he is insured, you should contact your insurance company just to cover any injury that could occur. Let them know your problem and discuss with your agent what you are attempting to accomplish.
   4. Make sure you keep the mares tail wrapped so he does not get any hair cuts on his penis while he is figuring out the fundamentals of breeding 101 at his own speed.

Second, why does the cooled transported semen need to have 100% of the air eliminated from the syringe, when the on-the-farm breeding calls for 50% air in the syringe? I have copied and pasted the protocols below.
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Anaerobic: Fresh cooled transport only at 8 degrees centigrade. Process the dose syringe without air present, eliminate 100% of the air from inside of the syringe.

Aerobic: On farm and/or immediate use at 15 degrees centrigrade. Process the syringe with 50% of the extended semen & 50% air present inside of the syringe.
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Thank you. I look forward to hearing back from you. Have a great day!
Sincerely, Tina